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4arm-PEG-SG

4arm-PEG-SG is a multi-arm PEG derivative containing four identical polyethylene glycol branches, which can be used to modify proteins, peptides, particles, etc. Succinimide glutarate can form stable amide bonds with amino groups.

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Material Chemistry

Analytical Chemicals

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Product introduction

PRODUCT NAME	4arm-PEG-SG
Other name	4arm PEG Succinimidyl Glutarate;4-arm Poly(ethylene glycol) succinimidyl glutarate;
Solubility	Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
MW	2000、 5000、 10000、 20000
DENSITY	1.125g/mL(Predicted)
APPEARANCE	White or yellowish liquid, semi-solid or solid, depending on molecular weight.
Storage	Freeze and dry below -20℃. Long-term storage inert (argon or nitrogen) protection.
DELIVERY	2-3DAYS
PACKAGE	According client's request

Description of 4arm-PEG-SG

4-Arm PEG-SG is a multiarmed PEG derivative with succinimidyl NHS ester at each terminal of the four arms connected to one pentaerythritol core. PEG-SG (succinimidyl glutarate ester) is one type of PEG-NHS reagents. There is a C4 hydrocarbon ester linkage between PEG and NHS ester.

Applications of 4arm-PEG-SG

4arm PEG Succinimidyl Glutarate (a.k.a., 4S-StarPEG) derivatives can be crosslinked into degradable PEG hydrogels. 4arm PEG Succinimidyl Glutarate is a cleavable labile PEG linker.

The cleavable ester linker between PEG and the NHS ester enables the feature of “degradable” hydrogels. PEG hydrogels have a variety of applications in medical devices and regenerative medicine, and are especially of interest for controlled release of drugs, for 2D and 3D cell culture, and for wound sealing and healing.

4 arm PEGs are synthesized by ethoxylation of pentaerythritol. The number of ethylene oxide units in the PEG chain may not be equal for all arms.

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