CAS:1916571-90-8 NCT-503
NAME:NCT-503 CAS:1916571-90-8 MF:C20H23F3N4S MW:408.48 PURITY:98%
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Product introduction
| NAME | NCT-503 |
| CAS | 1916571-90-8 |
| MF | C20H23F3N4S |
| MW | 408.48 |
| DENSITY | 1.306±0.06 g/cm3 |
| MP | |
| BP | 474.3±55.0 °C |
| STORAGE | 2-8°C |
Description
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM. It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM.
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