CAS:2022-78-8 5-FLUORO-2-HYDROXYPYRIMIDINE
NAME:5-FLUORO-2-HYDROXYPYRIMIDINE CAS:2022-78-8 MF:C4H3FN2O MW:114.08 PURITY:98%
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Material Chemistry
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Product introduction
| NAME | 5-FLUORO-2-HYDROXYPYRIMIDINE |
| CAS | 2022-78-8 |
| MF | C4H3FN2O |
| MW | 114.08 |
| DENSITY | 1.46±0.1 g/cm3 |
| MP | 170-174 °C |
| STORAGE | 2-8°C |
Description
Synthesis Analysis
The synthesis of 5-Fluoropyrimidin-2-one derivatives, such as 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, has been described through practical methodologies involving the conversion of commercially available 2,4-dichloro-5-fluoropyrimidine into key intermediates. This process involves several steps, including telescoped steps to tert-butyl 4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidine-1-carboxylate, which upon deprotection yields the desired product in significant overall yield, offering an economical synthesis pathway
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