CAS:221121-37-5 4-(4-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER
NAME:4-(4-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER CAS:221121-37-5 MF:C12H13FO3 MW:224.23 PURITY:98%
Categories:
Material Chemistry
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Product introduction
| NAME | 4-(4-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER |
| CAS | 221121-37-5 |
| MF | C12H13FO3 |
| MW | 224.23 |
| DENSITY | 1.161±0.06 g/cm3 |
| BP | 295.5±20.0 °C |
Description
Synthesis Analysis
The synthesis of Ethyl 4-(4-fluorophenyl)-3-oxobutanoate involves the Knoevenagel condensation reaction, a method demonstrated through the synthesis of structurally related compounds. For example, Ethyl 2-(4-fluorobenzylidene)-3-oxobutanoate was synthesized by reacting 4-fluorobenzaldehyde and ethyl acetoacetate in the presence of piperidine and trifluoroacetic acid under reflux conditions in benzene, showcasing the versatility of this synthesis approach in producing fluorophenyl compounds.
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