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CAS:22333-58-0 9-Hydroxy-alpha-lapachone

NAME:9-Hydroxy-alpha-lapachone CAS:22333-58-0 MF:C15H14O4 MW:258.27 PURITY:98%

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Material Chemistry

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NAME	9-Hydroxy-alpha-lapachone
CAS	22333-58-0
MF	C15H14O4
MW	258.27
DENSITY	1.35±0.1 g/cm3
MP	178-180 °C
BP	436.4±45.0 °C
STORAGE	2-8°C

Scientific Research ApplicationsSynthesis and Anticancer Properties
9-Hydroxy-alpha-lapachone, a derivative of α-lapachone, has been synthesized and evaluated for its anticancer properties. A study presented a synthetic method to obtain α- and β-pyran naphthoquinones with hydroxyl substituents, including 9-hydroxy-α-lapachone. These compounds displayed promising anticancer activities against several tumor cell lines, indicating their potential as anticancer agents. The enhanced pro-oxidant capacity of these compounds might contribute to their therapeutic efficacy .
Antiproliferative Activity
Further research on β-lapachone analogs, including α-lapachone derivatives, highlighted their significant antiproliferative activity in human solid tumor cell lines. The study emphasized the notable activity of 7-hydroxy-β-lapachone, a compound similar in structure to 9-hydroxy-α-lapachone, suggesting the potential of these derivatives in cancer therapy. The antiproliferative effects were associated with the induction of reactive oxygen species (ROS) and DNA damage .

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