CAS:2343-22-8 5-Fluoroindoline
NAME:5-Fluoroindoline CAS:2343-22-8 MF:C8H8FN MW:137.15 PURITY:98%
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Material Chemistry
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Product introduction
| NAME | 5-Fluoroindoline |
| CAS | 2343-22-8 |
| MF | C8H8FN |
| MW | 137.15 |
| DENSITY | 1.171 g/mL at 25 °C |
| MP | 116-118 °C |
| BP | 102-104°C 7mm |
| STORAGE | 2-8°C |
Description
5-Fluoroindoline is not directly discussed in the provided papers; however, the papers focus on 5-fluorouracil (5-FU), a chemotherapeutic agent used in the treatment of various cancers, particularly colorectal cancer. 5-FU is a fluorinated analogue of the nucleobase uracil and is metabolized in the body through pathways similar to uracil. It is known for its ability to interfere with DNA synthesis by inhibiting the enzyme thymidylate synthase, which is crucial for DNA replication . The papers provided discuss the clinical pharmacology of 5-FU, its combination with folinic acid (FA) to enhance its therapeutic effects, and various administration strategies to improve patient outcomes
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