CAS:58546-54-6 Gomisin A
NAME:Gomisin A CAS:58546-54-6 MF:C23H28O7 MW:416.47 PURITY:98%
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Material Chemistry
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Product introduction
| NAME | Gomisin A |
| CAS | 58546-54-6 |
| MF | C23H28O7 |
| MW | 416.47 |
| DENSITY | 1.1772 |
| MP | 88.5°C |
| BP | 454.79°C |
| STORAGE | Sealed in dry,Store in freezer, under -20°C |
Description
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity . It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells . It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day .
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