CAS:73590-93-9 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL
NAME:3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL CAS:73590-93-9 MF:C8H11Cl2N MW:192.08 PURITY:98%
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Material Chemistry
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Product introduction
| NAME | 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL |
| CAS | 73590-93-9 |
| MF | C8H11Cl2N |
| MW | 192.08 |
| MP | >145 |
| STORAGE | under inert gas (nitrogen or Argon) at 2-8°C |
Description
Synthesis Analysis
The synthesis of 2-(Chloromethyl)-3,5-dimethylpyridine hydrochloride and its derivatives has been approached through different pathways. One method involves the N-oxidation of 2,3-lutidine, followed by a series of reactions including methylation, oxidation, and chlorination to produce 2-chloromethyl-4-methanesulfonyl-3-methyl pyridine, which is a related intermediate . Another synthesis route starts from 2,3,5-trimethylpyridine and involves N-oxidation, nitration, methoxylation, acylation, and hydrolysis, followed by chlorination with SOCl2 to yield the title compound with an overall yield of 63.6% . Improvements on the synthesis have been made using a POCl3/CH2Cl2/Et3N system, which offers a highly selective chlorination from 2-methylpyridine N-oxide under mild conditions .
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