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CAS:942271-61-6 tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate

NAME:tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate CAS:942271-61-6 MF:C16H23N3O4 MW:321.37 PURITY:98%

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Material Chemistry

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Product introduction

NAME	tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
CAS	942271-61-6
MF	C16H23N3O4
MW	321.37
DENSITY	1.181±0.06 g/cm3
BP	449.8±45.0 °C

Description
Synthesis Analysis
The synthesis of compounds related to tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate involves various strategies. One approach includes the acylation of anilines with α-oxocarboxylic acids assisted by tert-butyl nitrite, which acts as a nitrosation reagent and an oxidant in Pd(ii)-catalyzed decarboxylative acylation . Another synthesis method involves the amination of 4-iodo-2-methyl-6-nitroaniline using CuI, ethylene glycol, and potassium phosphate to yield tert-butyl-4-(4-amino-3-methyl-5-nitrophenyl)piperazine-1-carboxylate, an important intermediate for the synthesis of biologically active benzimidazole compounds . Additionally, the synthesis of optical isomers of related compounds has been achieved through chiral column chromatography and deamination processes, which are crucial for the development of antilipidemic agents .

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