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CAS 41332-24-5 N-type calcium channel blocker NP-118809

CAS 41332-24-5 N-type calcium channel blocker NP-118809

Name:1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone CAS:41332-24-5 MF:C32H32N2O MW:460.61 Purity:98% Package:100g;1kg;10kg; Made in China Worldwide Delivery

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Product introduction

Introduction and application of CAS 41332-24-5 N-type calcium channel blocker NP-118809

Synonyms:

1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone;

1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine;

Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-;

Specification:

ITEMS	SPECIFICATION
CAS	41332-24-5
MF	C32H32N2O
MW	460.61
Melting point	N/A
Boiling point	618.9±55.0 °C(Predicted)
Density	1.142±0.06 g/cm3(Predicted)
Acidity coefficient	5.99±0.10(Predicted)
Color	Light yellow to yellow
Form	Powder
Storage condition	Sealed in dry,Room Temperature

Use:

NP118809 is an effective N-type calcium channel blocker with an IC50 value of 0.Chemicalbook11μM; it can also weakly inhibit the L-type calcium channel with an IC50 value of 12.2μM.

In vitro studies:

NP118809 is a potent N-type calcium channel blocker, with an IC 50 of 0.11 μM; also inhibits L-type calcium channel with an IC 50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC 50 of 7.4 μM.

In vivo studies:

NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.

Package and transportation:Normal

Package:100g;1kg;10kg;