CAS NO.22916-47-8 Miconazole
NAME:Miconazole CAS:22916-47-8 MF:C18H14Cl4N2O MW:416.13 PURITY:98%
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Material Chemistry
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Product introduction
| NAME | Miconazole |
| CAS | 22916-47-8 |
| MF | C18H14Cl4N2O |
| MW | 416.13 |
| EINECS | 245-324-5 |
| MP | 159-163C |
| BOILING POINT | 555.1±50.0 °C |
| STORAGE | Sealed in dry,Room Temperature |
Description
Synthesis Analysis
Miconazole's synthesis has evolved over the years to improve efficiency and yield. The traditional synthesis route involves the intermolecular insertion of a carbenoid species into imidazole, derived from α-diazoketones with copper acetylacetonate as a catalyst. This method presents a straightforward approach to producing miconazole and its analogs, such as enilconazole and econazole (E. Yáñez et al., 2004). Additionally, a novel chemoenzymatic route has been applied for the synthesis of miconazole, utilizing lipases and oxidoreductases for stereoselective processes, highlighting the importance of chirality in its biological evaluation
Applications
Gastrointestinal Applications : Miconazole gel enhances the cure rate of Helicobacter pylori infection when combined with lansoprazole and amoxicillin
Dermatological and Cosmetic Uses : It inhibits melanogenesis in B16 melanoma cells, which can benefit treatments for hyperpigmentation disorders like ephelis and melasma
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