CAS NO.3292-77-1 2-BROMO-1-(1,3-THIAZOL-2-YL)ETHANONE
NAME:2-BROMO-1-(1,3-THIAZOL-2-YL)ETHANONE CAS:3292-77-1 MF:C5H4BrNOS MW:206.06 PURITY:98%
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Material Chemistry
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Product introduction
| NAME | 2-BROMO-1-(1,3-THIAZOL-2-YL)ETHANONE |
| CAS | 3292-77-1 |
| MF | C5H4BrNOS |
| MW | 206.06 |
| MP | 206.06 |
| BOILING POINT | 266.7±42.0 °C |
| DENSITY | 266.7±42.0 °C |
| STORAGE | under inert gas (nitrogen or Argon) at 2-8°C |
Description:
The synthesis of thiazole derivatives can be achieved through various synthetic protocols. For instance, 1,3-dibromo-1,1-difluoro-2-propanone has been used as a synthon for the chemoselective preparation of bromodifluoromethyl thiazoles, which are valuable in drug discovery programs . Similarly, 2-bromo-1-(1H-pyrazol-4-yl)ethanone serves as a versatile precursor for the synthesis of novel mono-, bis-, and polythiadiazines, achieved by reacting with appropriate aminotriazolethiol or di- and poly(bromo) compounds . Additionally, α-bromo chalcones containing a 2-thiene ring have been prepared through the condensation of 1-(thien-3-yl)ethanone with aromatic aldehydes, followed by bromination and selective dehydrobromination.
Applications:
Biological Activities and Synthesis
The compound 1-(6-Bromo-3-methyl-1,3-thiazolo[3,2-a]benzimidazol-2-yl)ethanone, related to 2-Bromo-1-(thiazol-2-yl)ethanone, has been synthesized and found to exhibit potent immunosuppressive activities against macrophages and T-lymphocytes. It also demonstrates significant inhibition of LPS-stimulated NO generation and possesses cytotoxicity against various cancer cells .
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