CAS NO.51640-52-9 2-AMINOTHIAZOLE-5-CARBONITRILE
NAME:2-AMINOTHIAZOLE-5-CARBONITRILE CAS:51640-52-9 MF:C4H3N3S MW:125.15 PURITY:98%
Categories：
Material Chemistry
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Product introduction
| NAME | 2-AMINOTHIAZOLE-5-CARBONITRILE |
| CAS | 51640-52-9 |
| MF | C4H3N3S |
| MW | 125.15 |
| MP | 85-187 |
| DENNSITY | 1.45±0.1 g/cm3 |
| STORAGE | Keep in dark place,Inert atmosphere,2-8°C |
Description:
Synthesis Analysis
The synthesis of heteroazine fused thiazole-2-carbonitriles, which are closely related to 2-aminothiazole-5-carbonitrile, can be achieved through a two-step route starting from 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) and ortho- or para-chloro substituted meta-aminoazines. This process involves thermolysis and a subsequent BnEt(3)NI mediated ANRORC style ring transformation, yielding moderate to near quantitative yields.
Applications:
Synthesis and Medicinal Chemistry
2-Aminothiazole-5-carbonitrile is a versatile intermediate in medicinal chemistry and drug discovery projects. Havel et al. (2018) describe its use in the synthesis of 3,4-substituted-5-aminopyrazoles and 4-substituted-2-aminothiazoles, which are important for developing new pharmaceutical compounds .
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