CAS NO:103404-90-6 D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
CAS NO:103404-90-6 NAME:D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT MF：C5H9NaO5 MW：172.11 PURITY:95%MIN COA:Available
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Life Science Chemicals
Biochemicals
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Product introduction
| PRODUCT NAME | D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT |
| CAS NO | 103404-90-6 |
| MF | C5H9NaO5 |
| MW | 172.11 |
| MP | >291°C (dec.) |
| STORAGE | Inert atmosphere,Room Temperature |
| PACKAGE | According clients' request |
| DELIVERY | 2-3days |
Description of CAS NO:103404-90-6 D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
D-α-Hydroxyglutaric acid disodium salt is an α hydroxy acid, which is formed from the hydrolysis of (R)-5-oxo-2-tetrahydrofurancarboxylic acid. In humans the enzyme Hydroxyacid-oxoacid transhydrogenase catalyzes the formation of D-α-Hydroxyglutaric acid disodium salt, whereas in bacteria it is catalyzed by 2-hydroxyglutarate synthase. Sodium (R)-2-hydroxypentanedioate exhibits a diverse array of biochemical and physiological impacts. It influences glucose metabolism, insulin sensitivity, and blood pressure regulation. Moreover, it influences cell proliferation, apoptosis, and cell adhesion, as supported by scientific evidence.
The new analytical method for (R)-2-hydroxyglutaric acid disodium salt is based on the use of a multidimensional approach, including sensitivity, sensor enhancement, and metabolite profiling. This analytical method is highly sensitive and can be used to detect a single molecule of gadolinium in plasma samples. The method is also able to differentiate between different types of gadolinium compounds that are present in the sample, such as Gd(III) and Gd(IV). This new analytical method has been shown to have high sensitivity and selectivity when compared with other methods.
Biological Activity
(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).
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