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CAS NO:329-89-5 6-Aminonicotinamide

CAS NO:329-89-5 NAME:6-Aminonicotinamide MF：C6H7N3O MW：137.14 EINECS：206-349-7 Purity:97%+ Appearance:White to Light yellow powder COA:Provide

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Product introduction

PRODUCT NAME	6-Aminonicotinamide
CAS NO	329-89-5
MP	245-248 °C (lit.)
BP	251.97°C (rough estimate)
DENSITY	1.2620 (rough estimate)
STORAGE	2-8°C
DELIVERY	2-3DAYS
PACKAGE	According client's request

Description of CAS NO:329-89-5 6-Aminonicotinamide

6-Aminonicotinamide is an effective antimetabolite of nicotinamide . It is a competitive inhibitor of NADP+ dependent enzymes, such as glucose 6-phosphate dehydrogenase (G6PD) . It leads to ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as Cisplatin, to kill cancer cells.

Applications of CAS NO:329-89-5 6-Aminonicotinamide

1)Cancer Treatment: Targeting Metabolic Pathways
6-AN is used to target the pentose phosphate pathway (PPP), which is crucial for cancer cell proliferation.

2)Induction of Oxidative Stress
Treatment with 6-AN enhances oxidative stress in cancer cells.

3)Endoplasmic Reticulum Stress Modulation
6-AN affects the endoplasmic reticulum (ER) stress pathways. By inducing ER stress, 6-AN can reduce cell proliferation and govern cellular apoptosis, which is a beneficial effect in cancer therapy

Future Directions
Research is currently being conducted to explore the role of the pentose phosphate pathway in diseases like cancer and the potential of 6-Aminonicotinamide as a therapeutic agent . The efficient use of metabolic inhibitors like 6-Aminonicotinamide could be a clinically promising therapeutic scheme.

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