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CAS NO:700-49-2 2-Fluoroadenine

CAS NO:700-49-2 NAME:2-Fluoroadenine MF：C5H4FN5 MW：153.12 EINECS：624-159-6 PURITY:98% COA:Provide Sample:Negotiable Appearance:White to Light Yellow solid

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PRODUCT NAME	2-Fluoroadenine
CAS NO	700-49-2
MP	>350 °C(lit.)
BP	239.6±50.0 °C(Predicted)
DENSITY	2.05±0.1 g/cm3(Predicted)
STORAGE	Keep in dark place,Sealed in dry,Room Temperature
DELIVERY	2-3DAYS
PACKAGE	According client's request

Description of CAS NO:700-49-2 2-Fluoroadenine

2-Fluoroadenine CAS NO:700-49-2 is an inhibitor of DNA synthesis, which is used to study the effect of carcinogens on the cell cycle. It is a potent inducer of G2/M arrest in HL-60 cells, and has been shown to be cytotoxic to a number of different carcinoma cell lines. 2-Fluoroadenine disrupts collagen gel networks by binding to nitrogens in the protein matrix. This inhibits the glycosylation process that stabilizes collagen networks. The use of 2-fluoroadenine as a chemotherapeutic agent has been studied in animal models and clinical trials. 2-Fluoroadenine has been shown to inhibit mitochondrial membrane potential, leading to apoptosis caused by oxidative stress.

2-Fluoroadenine (2-FA) CAS NO:700-49-2 is a toxic adenine antimetabolite used in laboratory biological research for counterselection of wildtype bacterial or eukaryotic APT (adenine phosphoribosyltransferase) genes

Applications of CAS NO:700-49-2 2-Fluoroadenine

1)DNA Radiation Damage Sensitization
2-Fluoroadenine ((2F) A) is suggested for application in cancer radiotherapy due to its ability to sensitize DNA to low-energy electrons, enhancing DNA strand breakage and acting as an effective radiosensitizer across a wide range of electron energies

2)Metabolic Pathway Analysis
The metabolism of 2-Fluoroadenine, particularly its liberation from 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) and subsequent conversion to 2-fluoro-ATP, has been examined.

3)Nucleic Acid Structure and Function
The incorporation of 2-fluoroadenine (2FA) into DNA, impacting structures like the canonical right-handed DNA duplex, G-quadruplex, and i-motif, has been characterized.

4)Synthesis and Process Development
Advances in the synthesis of 2-fluoroadenine, such as the development of a one-step synthesis using hydrogen fluoride pyridine in continuous flow operation, are crucial for improving yield, purity, and process robustness of this pharmaceutical intermediate

5)Biologic Activity Analysis
Studies have explored the inhibitory activities of 2-fluoroadenine derivatives against biological targets like Plasmodium falciparum SAH hydrolase.

6)Cellular Transport and Metabolism
Research into the transport and phosphorylation of 2-fluoroadenosine in cells, studied through techniques like 19F-nuclear magnetic resonance (NMR) spectroscopy,provides valuable insights into the cellular mechanisms and metabolism of 2-fluoroadenine derivatives.

Future Directions
2-Fluoroadenine has been used in the treatment of chronic lymphocytic leukemia . The interest in 2-fluoroadenine nucleosides is increasing, with cytotoxic 2-fluoroadenosine and modified sugar analogues demonstrating resistance toward deamination by the catabolic enzyme adenosine deaminase and thus longer lifetimes in vivo

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