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8-Bromo-4-chromanone | CAS： 204377-88-8

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Introduction and application of 8-Bromo-4-chromanone | CAS： 204377-88-8

8-bromo-4-dihydrochromone Uses and synthesis methods Uses 8-bromo-4-dihydrochromone is an important intermediate with low yield and high difficulty in synthesis. Its sales price is more than twenty times that of similar product 6-bromo-3-dihydrochromone. There are few reports on the synthesis of 8-bromo-4-dihydrochromanone. Currently, there are three classic methods: one is to reflux 3-bromophenol and halogenated propionic acid under alkaline conditions to obtain sodium aryloxypropionate, which is then acidified with hydrochloric acid to obtain aryloxypropionic acid, and then dehydrated with concentrated sulfuric acid at room temperature or dehydrated with polyphosphoric acid under microwave irradiation to obtain chromanone, or convert aryloxypropionic acid into acyl chloride with oxalyl chloride and then undergo Friedel-Crafts acylation under the action of anhydrous AICI to obtain 8-bromo-4-dihydrochromanone; the second is to use synthesized 8-bromo-4-tetrahydrochromanone as a raw material and reduce it with diisobutylaluminum hydride (DIBAL-H) at -80°C to obtain 8-bromo-4-dihydrochromanone; the third is to use bromophenol and acrylonitrile under alkaline conditions to obtain aryloxypropionitrile, and then hydrolyze and directly cyclize under trifluoromethanesulfonic acid (TfOH) to obtain 8-bromo-4-dihydrochromanone.

Specification of 8-Bromo-4-chromanone | CAS： 204377-88-8

Boiling point 339℃
Density 1.621
Flash point 159℃
Storage conditions Sealed in dryness, Room Temperature

Package of 8-Bromo-4-chromanone | CAS： 204377-88-8

Specifications: 1kg,10kg,100kg, 1000kg (can be packaged according to customer needs)
Function and use: This product is used for content determination and not for other purposes.
Storage method: 2-8°C, store in a cool and dry place, away from light.
Note: This product should be stored at low temperature. The content will decrease if exposed to air for a long time.

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