(S)-(+)-Epichlorohydrin | CAS:67843-74-7
MF： C3H5ClO MW： 92.52 CAS： 67843-74-7 Made in China Worldwide delivery
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Material Chemistry
Life Science Chemicals
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Product introduction
Introduction and application of (S)-(+)-Epichlorohydrin | CAS:67843-74-7
Chemical properties: Dextrorotatory epichlorohydrin is a colorless or light yellow liquid at room temperature and pressure. The epoxy ring in its structure has high tension and instability, so the three-membered ring of dextrorotatory epichlorohydrin is easy to undergo ring-opening reactions. The ring-opening reaction of the epoxy ring usually occurs under the attack of nucleophilic reagents, such as water, alcohol, amine, etc., to form the corresponding ring-opening products. For example, the ring-opening reaction of the epoxy ring can react with water to form glycidol. Application: Dextrorotatory epichlorohydrin is a derivative of propylene oxide, which is mostly used as an intermediate in organic synthesis and pharmaceutical chemistry, and is mostly used in the synthesis and modification of chiral drug molecules and bioinhibitors. Synthesis Add (S)-3-chloropropane-1,2-diol (20.0 g, 181 mmol) and potassium carbonate (30 g, 217 mmol) to a dry reaction flask, and finally add tetrahydrofuran as the reaction solvent. Heat the resulting reaction mixture to reflux and stir the reaction under reflux for 10 h. After the reaction is completed, evaporate the solvent directly from the reaction mixture under reduced pressure to obtain the target product. It should be noted that the product dextrorotatory epichlorohydrin has a low boiling point, so special attention should be paid during post-treatment. Figure Synthesis route of dextrorotatory epichlorohydrin Chemical properties Boiling point 92-93 °C (360 mmHg). Uses As a potential metabolic regulator, it is used to synthesize fatty acid oxidation inhibitors; used in the total synthesis of Macquarimicins and the total synthesis of macrolide RK-397; used for the enantioselective synthesis of chiral structural units of hydroxyisoxazolidine and (+)-cis-sylvaticin (a potential anti-tumor agent) Uses Dextrorotatory epichlorohydrin can be used for the synthesis of chiral intermediates and chiral drugs. Safety Information
Specification of (S)-(+)-Epichlorohydrin | CAS:67843-74-7
Melting point −57°C (lit.)
Boiling point 92-93°C 360mmHg (lit.)
Specific rotation 34º (589nm, c=1, MeOH)
Density 1.183g/mLat25°C (lit.)
Vapor density 3.2 (vsair)
Vapor pressure 13.8mmHg (21.1°C)
Refractive index n20/D 1.438 (lit.)
Flash point 93°F
Storage conditions Inertatmosphere, 2-8°C
Solubility Soluble in chloroform, methanol (a little)
Form Liquid
Color Transparent Colorless to Very Light Yellow
Package of (S)-(+)-Epichlorohydrin | CAS:67843-74-7
Specifications: 1kg,25kg,200kg, 1000kg (can be packaged according to customer needs)
Function and use: This product is used for content determination and not for other purposes.
Storage method: 2-8°C, store in a cool and dry place, away from light.
Note: This product should be stored at low temperature. The content will decrease if exposed to air for a long time.
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